European Research Infrastructure for Heritage Science (E-RIHS) is an initiative that supports research on heritage interpretation, conservation, documentation and management. Cutting-edge tools and services will be provided by cross-disciplinary groups of researchers to cross-disciplinary users and scientific communities working to advance knowledge about heritage and to devise innovative strategies for its conservation. E-RIHS connects researchers in the humanities and natural sciences and fosters a trans-disciplinary culture of exchange and cooperation. It pursues the integration of European world-class facilities to create a cohesive entity, playing a connecting role in the global community of heritage science.